Throughout the animal kingdom, p53 genes function to restrain mobile elements and recent observations indicate that transposons become derepressed in human cancers. Together, these emerging lines of evidence suggest that cancers driven by p53 mutations could represent “transpospoathies,” i.e. disease states linked to eruptions of mobile elements. The transposopathy hypothesis predicts that p53 acts through conserved mechanisms to contain transposon movement, and in this way, prevents tumor formation. How transposon eruptions provoke neoplasias is not well understood but, from a broader (...) perspective, this hypothesis also provides an attractive framework to explore unrestrained mobile elements as inciters of late‐onset idiopathic disease.Also see the video abstract here. (shrink)

Rules are meant to apply equally to all within their jurisdiction. However, some rules are frequently broken without consequence for most. These rules are only occasionally enforced, often at the discretion of a third-party observer. We propose that these rules—whose violations are frequent, and enforcement is rare—constitute a unique subclass of explicitly codified rules, which we call ‘phantom rules’ (e.g., proscribing jaywalking). Their apparent punishability is ambiguous and particularly susceptible to third-party motives. Across six experiments, (N = 1440) we validated (...) the existence of phantom rules and found evidence for their motivated enforcement. First, people played a modified Dictator Game with a novel frequently broken and rarely enforced rule (i.e., a phantom rule). People enforced this rule more often when the “dictator” was selfish (vs. fair) even though the rule only proscribed fractional offers (not selfishness). Then we turned to third person judgments of the U.S. legal system. We found these violations are recognizable to participants as both illegal and commonplace (Experiment 2), differentiable from violations of prototypical laws (Experiments 3) and enforced in a motivated way (Experiments 4a and 4b). Phantom rule violations (but not prototypical legal violations) are seen as more justifiably punished when the rule violator has also violated a social norm (vs. rule violation alone)—unless the motivation to punish has been satiated (Experiment 5). Phantom rules are frequently broken, codified rules. Consequently, their apparent punishability is ambiguous, and their enforcement is particularly susceptible to third party motives. (shrink)

Given the diversity of explanatory practices that is typical of the sciences a healthy pluralism would seem to be desirable where theories of explanation are concerned. Nevertheless, I argue that explanations are only unifying in Kitcher's unificationist sense if they are backed by the kind of understanding of underlying mechanisms, dispositions, constitutions, and dependencies that is central to a causalist account of explanation. This case can be made through analysis of Kitcher's account of the conditions under which apparent improvements in (...) unifying power may be judged spurious. But to clarify what is at issue I consider an archaeological case in which debate about the merits of an ambitious explanatory account reproduces exactly the intuitions that divide Salmon and Kitcher. The case in question is the “demic-diffusion” account of contemporary linguistic diversity advanced by Renfrew in the late 1980s: the thesis that the diffusion of agricultural populations, itself attributed to demographic pressure, was responsible for the spread of the ancestral root languages (e.g., proto-Indo-Eurpoean) that account for the existence and distribution of linguistic macrofamilies. The credibility of this powerfully unifying argument pattern depends entirely on the plausibility of its claims about the conditions and mechanisms actually responsible for the explanandum, the spread of agriculture, and not on an elaboration of its unificationist virtues. (shrink)

ICAP is a theory of active learning that differentiates students’ engagement based on their behaviors. ICAP postulates that Interactive engagement, demonstrated by co‐generative collaborative behaviors, is superior for learning to Constructive engagement, indicated by generative behaviors. Both kinds of engagement exceed the benefits of Active or Passive engagement, marked by manipulative and attentive behaviors, respectively. This paper discusses a 5‐year project that attempted to translate ICAP into a theory of instruction using five successive measures: (a) teachers’ understanding of ICAP after (...) completing an online module, (b) their success at designing lesson plans using different ICAP modes, (c) fidelity of teachers’ classroom implementation, (d) modes of students’ enacted behaviors, and (e) students’ learning outcomes. Although teachers had minimal success in designing Constructive and Interactive activities, students nevertheless learned significantly more in the context of Constructive than Active activities. We discuss reasons for teachers’ overall difficulty in designing and eliciting Interactive engagement. (shrink)

Insofar as the material residues of interest to archaeologists are cultural and, as such, have specifically symbolic significance, it is argued that archaeology must employ some form of structuralist analysis (i.e. as specifically concerned with this aspect of the material). Wylie examines the prevalent notion that such analysis is inevitably 'unscientific' because it deals with a dimension of material culture which is inaccessible of any direct, empirical investigation, and argues that this rests on an entrenched misconception of science; it (...) assumes that scientific enquiry must be restricted to observables. It is clear, as realist critics of this view have argued, that scientific (explanatory) understanding depends fundamentally on theoretical extensions beyond observables; extensions which bring into view underlying and inaccessible causal structures or mechanisms responsible for the mani- fest phenomena through a procedure of analogical model construc- tion. In consideration of realist models of these procedures and of the potential of linguistic modes of analysis for archaeology, it is pro- posed that archaeologists might (and, in fact, often do) effectively grasp the symbolic, structural order of surviving material culture through analysis governed by a rigorous and controlled use of ethno- graphic analogy. It is claimed, moreover, that the archaeological record can provide empirical bases for evaluating these theoretical constructs if a procedure of recursive and systematic testing is adopted in research, but the standard hypothetico-deductive model is seriously flawed as an account of an ideal for this procedure. Glassie's analysis of Middle Virginian folk housing is an example of research along these lines which illustrates the potential for a rigorous structuralist alternative. (shrink)

Glymour’s boostrapping account of confirmation is meant to show how it is that evidence can bear on a theory in a discriminating, noncircular way even when that theory is used to establish the inferential link between evidence and a test hypothesis. Evidence confirms a theory on his account if, “using the theory, we can deduce from the evidence an instance of the hypothesis i.e., an hypothesis comprising or instantiating the test theory, and the deduction is such that it does not (...) guarantee that we would have gotten an instance of the hypothesis regardless of what the evidence might have been.” (1980, p. 127). Glymour goes on to argue that this strategy of inference should appear most explicitly in the developing and “un-natural” (social) sciences where novel theories are being formulated or applied to new domains (1980, p. 172). (shrink)

I explore the relevance of feminist standpoint theory for understanding the development of gender research in archaeology. This is an approach to thinking about questions about gender in archaeology that I find fruitfully articulated in Jane Kelley and Marsha Hanen's analysis of the 1989 Chacmool abstracts. As standpoint theory has been reformulated in recent years it offers a strategy for understanding critically and constructively-what is (and is not) feminist about gender archaeology, and it suggests some guidelines for realizing "strong objectivity" (...) (as Harding describes it) in archaeological contexts. (shrink)

Inhibition, an executive function, is critical for achieving goals that require suppressing unwanted behaviours, thoughts, or distractions. One hypothesis of the emotion and goal compatibility theory is that emotions of sadness and fear enhance inhibitory control. Across Experiments 1–4, we tested this hypothesis by inducing a happy, sad, fearful, and neutral emotional state prior to completing an inhibition task that indexed a specific facet of inhibition (oculomotor, resisting interference, behavioural, and cognitive). In Experiment 4, we included an anger induction to (...) examine whether valence or motivational-orientation best-predicted performance. We found support that fear and sadness enhanced inhibition except when inhibition required resisting interference. We argue that sadness and fear enhance inhibitory control aiding the detection and analysis of problems (i.e. sadness) or threats (i.e. fear) within one’s environment. In sum, this work highlights the importance of identifying how negative emotions can be beneficial for and interact with specific executive functions influencing down-stream processing including attention, cognition, and memory. (shrink)

Reviews the book, Readings in the philosophy of social science, edited by Michael Martin and Lee C. McIntyre . This is a large and comprehensive anthology in the philosophy of the social sciences. It offers not only well-selected readings but also three specially commissioned articles by Michael Martin, Daniel Little, and Alison Wylie. The book is divided into eight major sections that address topics such as: Prediction, Reductionism, Interpretation and Meaning, Rationality, Objectivity and Values, Individualism and Holism, and Functional (...) Explanation. 2012 APA, all rights reserved). (shrink)

Muitos termos possuem um sentido técnico sem que ele seja evidente para todos, por exemplo, a "governança ambiental", termo que remete no contexto atual a uma participação cidadã nesse tipo de questão, por exemplo, da saúde de um ecossistema específico, tal como uma floresta ou um vale agrícola, a partir de preocupações partilhadas e não a partir de uma problemática de controle organizacional. Após ter tornado preciso o que é a expertise e quais são os principais problemas postos pelo recurso (...) à expertise nos contextos da ação cidadã, proponho que as expertises técnicas podem ser postas no mesmo patamar que outros tipos de expertise, referindo principalmente aos saberes comuns, à prática e à experiência concreta, dita "de campo", o que corresponde a uma ampliação. Sugere-se, então, o modelo de fórum híbrido como quadro teórico possível dessa reformulação da concepção de expertise. Many terms have a technical meaning although it is not evident for everyone, for example, the "environmental governance", term that refers in the present context to citizen participation on this type of question, for example, of the health of a specific ecosystem, such as a forest or an agricultural field, from shared preoccupations and not from a problematic of organizational control. After having made precise what is the expertise and what are the main problems posed by the recourse to the expertise in the contexts of citizen action, I propose that technical expertise can be tantamount to other types of expertise, referring mainly to profane knowledge, to the practice and concrete experience called "of field", which corresponds to an enlargement. Then it is suggested the model of an hybrid forum as a possible theoretical frame of this reformulation of the conception of expertise. (shrink)

Academia is fascinated by the process of how Western science and mathematical knowledge converged with the Chinese mathematical tradition. This topic not only reflects East–West interaction, but also turns upon the philosophical question of whether the Chinese have the scientific or cognitive ability to comprehend critical, logical, and abstract thinking. Fundamental to mathematical knowledge is arithmetic, which deals with numbers and their operations. This paper re-evaluates the significance of Alexander Wylie’s (1815–1887) pioneering role in translating Western arithmetical knowledge in (...) China, through (1) unearthing a mathematician-missionary, Edward Moncrieff (1824–1857), who compiled a textbook of arithmetic and translated associated mathematical knowledge, in particular Euclidian geometry, one year earlier than Wylie, and (2) critically analyzing the concept of arithmetic in their textbooks by means of the method of Begriffsgeschichte. (shrink)

Two fundamental rules of reasoning are Universal Generalisation and Existential Instantiation. Applications of these rules involve stipulations such as ‘Let n be an arbitrary number’ or ‘Let John be an arbitrary Frenchman’. Yet the semantics underlying such stipulations are far from clear. What, for example, does ‘n’ refer to following the stipulation that n be an arbitrary number? In this paper, we argue that ‘n’ refers to a number—an ordinary, particular number such as 58 or 2,345,043. Which one? We do (...) not and cannot know, because the reference of ‘n’ is fixed arbitrarily. Underlying this proposal is a more general thesis: Arbitrary Reference : It is possible to fix the reference of an expression arbitrarily. When we do so, the expression receives its ordinary kind of semantic-value, though we do not and cannot know which value in particular it receives. Our aim in this paper is defend AR. In particular, we argue that AR can be used to provide an account of instantial reasoning, and we suggest that AR can also figure in offering new solutions to a range of difficult philosophical puzzles. (shrink)

Standpoint theory is based on the insight that those who are marginalized or oppressed have distinctive epistemic resources with which to understand social structures. Inasmuch as these structures shape our understanding of the natural and lifeworlds, standpoint theorists extend this principle to a range of biological and physical as well as social sciences. Standpoint theory has been articulated as a social epistemology and as an aligned methodological stance. It provides the rationale for ‘starting research from the margins’ and for expanding (...) the diversity of backgrounds and experience represented in scientific communities. (shrink)

Ethicists and social scientists alike have advocated for the inclusion of vulnerable populations in research and decision-making on climate engineering. Unfortunately, there have been few efforts to do so. The research presented in this paper was designed to build knowledge about how vulnerable populations think about climate engineering. The goal of this manuscript is to bring the ethics literature on climate engineering into dialogue with emerging social science data documenting the perspectives of vulnerable populations. The results indicate some concerns among (...) vulnerable populations may resemble those outlined by ethicists. However, the perspectives expressed by interviewees also extend previous ethical treatments by indicating ways in which climate engineering could compound existing injustices. (shrink)

Standpoint theory is an explicitly political as well as social epistemology. It’s distinctive features are commitment to understand the social locations that shape the epistemic capacities and resources of individuals in structural terms, and a recognition that those who are marginalized within hierarchically structured systems of social differentiation are often epistemically advantaged. In some crucial domains they know more and know better as a contingent function of their situated experience and knowledge. This “inversion thesis” counters the alignment of social with (...) epistemic privilege. (shrink)

Material traces of the past are notoriously inscrutable; they rarely speak with one voice, and what they say is never unmediated. They stand as evidence only given a rich scaffolding of interpretation which is, itself, always open to challenge and revision. And yet archaeological evidence has dramatically expanded what we know of the cultural past, sometimes demonstrating a striking capacity to disrupt settled assumptions. The questions we address in Evidential Reasoning are: How are these successes realized? What gives us confidence (...) in the credibility and robustness, the trustworthiness, of the evidential claims based on archaeological data? And, what constitute best practices in building evidential claims, critically scrutinizing them and putting them to work in archaeological contexts? Rather than retreat to abstractions about how how science operates in the ideal, we approach this question by interrogating a number of close-to-the-ground case studies with the aim of teasing out the wisdom embodied in archaeological practice. The cases we consider – of fieldwork, strategies for working with old evidence, and the role of external resources – illuminate the role of various types of inferential scaffolding and bring into focus practice-grounded epistemic norms that we believe serve archaeologists better than the all-or-nothing ideals of truth and objectivity that dominate programmatic debate. (shrink)

Neither the range of potential results from genomic research that might be returned to participants nor future uses of stored data and biospecimens can be fully predicted at the outset of a study. Informed consent procedures require clear explanations about how and by whom decisions are made and what principles and criteria apply. To ensure trustworthy research governance, there is also a need for empirical studies incorporating public input to evaluate and strengthen these processes.

I develop a theory of what we mean by the 'look' sentences that we use to describe our visual experiences, and on that basis develop a new adverbial theory of what it is to have a visual experience with a certain character.

My main aim is to clarify what we mean by ‘look’ sentences such as (1) below – ones that we use to talk about visual experience: -/- (1) The ball looked red to Sue -/- This is to help better understand a part of natural language that has so far resisted treatment, and also to help better understand the nature of visual experience. -/- By appealing to general linguistic principles I argue for the following account. First, we use (1) to (...) talk about an event. Second, we use the verb ‘look’ to specify the kind of event about which we are talking – it is a looking event. Third, we use the subject ‘the ball’ to specify a stimulus of the event – something that looks some way in the event. Fourth, we use the adjunct ‘to Sue’ to specify an experiencer of the event – someone to whom things look some way in the event. Finally, we use the complement ‘red’ to specify a way of the event – a way in which the event occurs (I take ways of occurring to be properties of events). Which way do we use ‘red’ in (1) to specify? I argue: the maximally specific way w such that the following is generically true: looking events whose stimulus is red occur in way w (it is important that this is understood generically: this is what does much of the work in explaining our use of (1) and other ‘look’ sentences). Putting this together, what we mean by (1) is: there was a looking event whose stimulus was the ball, whose experiencer was Sue, and which occurred in the maximally specific way that looking events occur when their stimulus is red. -/- This account of how we use ‘red’ in (1) is one of the most interesting aspects of my thesis. It extends to an account of how we use ‘proud’ in ‘John walks proud’, ‘as if he is American’ in ‘John talks as if he is American’, ‘like a duck’ in ‘John sounds like a duck’, and so on. In each case we use the expression in question to specify a way: the maximally specific way proud people walk, the maximally specific way American people talk, and so on. So the study of ‘look’ sentences has much to tell us about the functioning of many other English language constructions, and suggests that ways have a significant role to play in the semantics of natural language – a fact that has not yet been sufficiently recognised by linguists or philosophers of language. -/- My thesis also has implications for the philosophy of perception. One of the central questions about perception is: What is the nature of visual experience? What is it, for example, for a ball to look red to Sue? My thesis offers an answer: What it is for the ball to look red to Sue is for whatever it is that we mean by ‘The ball looks red to Sue’ to be the case, and what we mean by ‘The ball looks red to Sue’ is that there is a looking event whose stimulus is the ball, whose experiencer is Sue, and which is occurring in a certain way. It thus delivers an adverbial account of visual experience, one that has the resources to better deal with problems that are traditionally thought to be decisive against adverbial accounts. (shrink)

Solidarity means standing with others: expressing support in times of stress and working together toward shared goals. As Saunkeah and colleagues note, solidarity also incorp...

Michael Smith attempts to solve the moral problem by arguing that our moral beliefs constitute a rational constraint on our desires. In particular, Smith defends the ‘practicality requirement’, which says that rational agents who believe that an action is right must have some desire to perform that action. We clarify and examine Smith’s argument. We argue that, for the argument to be sound, it must make two crucial assumptions about the rational agent in question: that facts about her desires are (...) transparent to her, and that she believes that she is rational. We conclude that if Smith has solved the moral problem then he has done so only for a restricted class of subjects—those who satisfy these two assumptions. (shrink)

The contributions to Testing Scientific Theories are unified by an in-terest in responding to criticisms directed by Glymour against existing models of confirmation—chiefly H-D and Bayesian schemas—and in assessing and correcting the "bootstrap" model of confirmation that he proposed as an alternative in Theory and Evidence (1980). As such, they provide a representative sample of objections to Glymour's model and of the wide range of new initiatives in thinking about scientific confirmation that it has influenced. The effect is a sense (...) of engagement and focus, and of significant advance at least in articulation of the problems that require solution; as Earman observes, "it is . . . heartening to report that the various opposing camps learned from each other" (p. vi).' In what follows I am concerned to assess what has been learned both critically, about Glymour's model, and constructively about the resources of the alternatives he challenges. My thesis is that while the theories emerging in this debate do deal with a wider range of scientific practice than before, their remaining limitations raise important questions about the ambitions and criteria of adequacy that have traditionally governed philosophical inquiry in this area. (shrink)

Research on bodies and sexualities has long debated ideas about choice, agency, and power, particularly as women conform to, or rebel against, traditional social scripts about femininity and heterosexuality. In this study, I have used responses from 34 college women who completed an extra credit assignment in a women’s studies class that asked them to reject social norms and grow out their leg and underarm hair for a period of 10 weeks. Responses reveal that women confronted direct and anticipated homophobia (...) and heterosexism from others as well as hostility for rejecting traditional norms of femininity. Heterosexual women regularly encountered demands that they acquire permission to grow body hair from their male partners, while queer and bisexual women expressed reluctance about further “outing” themselves via their body hair. I consider implications for linking sexual identity discrimination and body hair practices, and for imagining bodies as sites of resistance inside and outside of pedagogical settings. (shrink)

Moving from viruses, vaccines, and copycat murder to gay panics, xenophobia, and psychopaths, _Transforming Contagion_ energetically fuses critical humanities and social science perspectives into a boundary-smashing interdisciplinary collection on contagion. The contributors provocatively suggest contagion to be as full of possibilities for revolution and resistance as it is for the descent into madness, malice, and extensive state control. The infectious practices rooted in politics, film, psychological exchanges, social movements, the classroom, and the circulation of a literary text or meme on (...) social media compellingly reveal patterns that emerge in those attempts to re-route, quarantine, define, or even exacerbate various contagions. (shrink)

Existential instantiation is a rule of inference that allows us infer, from the proposition that there are some p things, the proposition that a is a p thing. What role does 'a' play here? According to one account, recently defended by Breckenridge and Magidor, we use 'a' to refer to a p thing. I argue that this cannot be right. I propose an alternative account, according to which we use 'a' to refer to a supposedly p thing.